論文 - 詳細
RRC ID | 47915 |
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著者 | Xu J, Hao X, Yin MX, Lu Y, Jin Y, Xu J, Ge L, Wu W, Ho M, Yang Y, Zhao Y, Zhang L. |
タイトル | Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. |
ジャーナル | Development |
Abstract |
The Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation. |
巻・号 | 144(8) |
ページ | 1510-1517 |
公開日 | 2017-4-15 |
DOI | 10.1242/dev.141341 |
PII | dev.141341 |
PMID | 28242614 |
MeSH | Animals Carcinogenesis / pathology Cell Dedifferentiation Cell Differentiation* Drosophila Proteins / antagonists & inhibitors* Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Gene Knockdown Techniques Intracellular Signaling Peptides and Proteins / metabolism Medulla Oblongata / cytology* Membrane Proteins / metabolism Neurons / cytology* Neurons / metabolism* Optic Lobe, Nonmammalian / anatomy & histology Optic Lobe, Nonmammalian / cytology Receptors, Notch / antagonists & inhibitors* Receptors, Notch / metabolism Signal Transduction Transcription Factors / metabolism* Up-Regulation Zinc Fingers |
IF | 5.611 |
引用数 | 5 |
WOS 分野 | DEVELOPMENTAL BIOLOGY |
リソース情報 | |
ショウジョウバエ |