論文 - 詳細
| RRC ID | 48104 |
|---|---|
| 著者 | Tanaka K, Masu M, Nakanishi S. |
| タイトル | Structure and functional expression of the cloned rat neurotensin receptor. |
| ジャーナル | Neuron |
| Abstract |
A functional cDNA clone for the rat neurotensin receptor was isolated by combining molecular cloning in an RNA expression vector with an electrophysiological assay in Xenopus oocytes. The neurotensin receptor consists of 424 amino acids with seven putative transmembrane domains and belongs to the family of G protein-coupled receptors. The cloned receptor expressed in mammalian cells or in Xenopus oocytes shows a selective and high-affinity binding to neurotensin peptides and undergoes potent desensitization by repeated application of neurotensin. The neurotensin receptor mRNA is expressed in both the brain and the peripheral tissues at different levels. This investigation discloses the molecular nature of the neurotensin receptor, which mediates the diverse neuronal and peripheral actions of neurotensin by effecting the G protein-associated second messenger system. |
| 巻・号 | 4(6) |
| ページ | 847-54 |
| 公開日 | 1990-6-1 |
| DOI | 10.1016/0896-6273(90)90137-5 |
| PII | 0896-6273(90)90137-5 |
| PMID | 1694443 |
| MeSH | Amino Acid Sequence Animals Base Sequence Binding, Competitive Cell Line Cloning, Molecular / methods Female GTP-Binding Proteins / genetics GTP-Binding Proteins / metabolism Gene Expression Kinetics Molecular Sequence Data Neurotensin / metabolism* Nucleic Acid Hybridization Oocytes / metabolism Organ Specificity Poly A / genetics RNA / genetics RNA, Messenger / genetics RNA, Messenger / metabolism Rats Receptors, Neurotensin Receptors, Neurotransmitter / genetics* Receptors, Neurotransmitter / metabolism Recombinant Proteins / metabolism Sequence Homology, Nucleic Acid Xenopus laevis |
| IF | 14.415 |
| 引用数 | 485 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 31 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 遺伝子材料 | prNTR 2 ( full8-6 ) (RDB13190) |