論文 - 詳細
| RRC ID | 49574 |
|---|---|
| 著者 | Kucinski I, Dinan M, Kolahgar G, Piddini E. |
| タイトル | Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status. |
| ジャーナル | Nat Commun |
| Abstract |
Cell competition is a form of cell interaction that causes the elimination of less fit cells, or losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can cause cells to become losers; however, it is not known how. Here we show that Drosophila wing disc cells carrying functionally unrelated loser mutations (Minute and mahjong) display the common activation of multiple stress signalling pathways before cell competition and find that these pathways collectively account for the loser status. We find that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. Furthermore, we show that losers display oxidative stress response activation and, strikingly, that activation of this pathway alone, by Nrf2 overexpression, is sufficient to prime cells for their elimination by WT neighbours. Since oxidative stress and Nrf2 are linked to several diseases, cell competition may occur in a number of pathological conditions.Cell competition causes the removal of less fit cells ('losers') but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status. |
| 巻・号 | 8(1) |
| ページ | 136 |
| 公開日 | 2017-7-26 |
| DOI | 10.1038/s41467-017-00145-y |
| PII | 10.1038/s41467-017-00145-y |
| PMID | 28743877 |
| PMC | PMC5526992 |
| MeSH | Animals Animals, Genetically Modified Apoptosis / genetics Cell Proliferation / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Enzyme Activation Gene Expression Profiling / methods Imaginal Discs / cytology JNK Mitogen-Activated Protein Kinases / genetics JNK Mitogen-Activated Protein Kinases / metabolism Janus Kinases / genetics Janus Kinases / metabolism Microscopy, Confocal Mutation Oxidative Stress* STAT Transcription Factors / genetics STAT Transcription Factors / metabolism Signal Transduction* Transcription Factors / genetics Transcription Factors / metabolism Wings, Animal / cytology |
| IF | 12.121 |
| 引用数 | 30 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | HMS00398 |