RRC ID 49696
Author Turner KJ, Hawkins TA, Yáñez J, Anadón R, Wilson SW, Folgueira M.
Title Afferent Connectivity of the Zebrafish Habenulae.
Journal Front Neural Circuits
Abstract The habenulae are bilateral nuclei located in the dorsal diencephalon that are conserved across vertebrates. Here we describe the main afferents to the habenulae in larval and adult zebrafish. We observe afferents from the subpallium, nucleus rostrolateralis, posterior tuberculum, posterior hypothalamic lobe, median raphe; we also see asymmetric afferents from olfactory bulb to the right habenula, and from the parapineal to the left habenula. In addition, we find afferents from a ventrolateral telencephalic nucleus that neurochemical and hodological data identify as the ventral entopeduncular nucleus (vENT), confirming and extending observations of Amo et al. (2014). Fate map and marker studies suggest that vENT originates from the diencephalic prethalamic eminence and extends into the lateral telencephalon from 48 to 120 hour post-fertilization (hpf). No afferents to the habenula were observed from the dorsal entopeduncular nucleus (dENT). Consequently, we confirm that the vENT (and not the dENT) should be considered as the entopeduncular nucleus "proper" in zebrafish. Furthermore, comparison with data in other vertebrates suggests that the vENT is a conserved basal ganglia nucleus, being homologous to the entopeduncular nucleus of mammals (internal segment of the globus pallidus of primates) by both embryonic origin and projections, as previously suggested by Amo et al. (2014).
Volume 10
Pages 30
Published 2016-1-1
DOI 10.3389/fncir.2016.00030
PMID 27199671
PMC PMC4844923
MeSH Afferent Pathways / physiology* Amino Acids / metabolism Animals Animals, Genetically Modified Basal Ganglia Brain Mapping* Calbindin 2 / genetics Calbindin 2 / metabolism Embryo, Nonmammalian Functional Laterality Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology* Glutamic Acid / metabolism Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Habenula / cytology Habenula / growth & development Habenula / physiology* Larva Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / metabolism Olfactory Bulb Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism
IF 3.156
Times Cited 31
Zebrafish Tg(CM-isl1:GFP)