論文 - 詳細
| RRC ID | 50070 |
|---|---|
| 著者 | Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS, Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo PM, Greter M, Chan JKY, Amit I, Beyer M, Schultze JL, Schlitzer A, Pettersson S, Ginhoux F, Garel S. |
| タイトル | Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. |
| ジャーナル | Cell |
| Abstract |
Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion. Finally, human fetal microglia exhibited significant overlap with the murine transcriptomic signature. Our study shows that microglia respond to environmental challenges in a sex- and time-dependent manner from prenatal stages, with major implications for our understanding of microglial contributions to health and disease. |
| 巻・号 | 172(3) |
| ページ | 500-516.e16 |
| 公開日 | 2018-1-25 |
| DOI | 10.1016/j.cell.2017.11.042 |
| PII | S0092-8674(17)31432-0 |
| PMID | 29275859 |
| PMC | PMC5786503 |
| MeSH | Animals Brain / cytology Brain / embryology Brain / metabolism Cell Differentiation Cells, Cultured Chromatin Assembly and Disassembly Female Germ-Free Life* Humans Male Mice Mice, Inbred C57BL Microbiota* Microglia / cytology* Microglia / metabolism Pregnancy Prenatal Exposure Delayed Effects / microbiology* Sex Factors Transcriptome* |
| IF | 38.637 |
| 引用数 | 164 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 307 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02704 |