Reference - Detail
| RRC ID | 51450 |
|---|---|
| Author | DeBardeleben HK, Lopes LE, Nessel MP, Raizen DM. |
| Title | Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans. |
| Journal | Genetics |
| Abstract |
Stress-induced sleep (SIS) in Caenorhabditis elegans is important for restoration of cellular homeostasis and is a useful model to study the function and regulation of sleep. SIS is triggered when epidermal growth factor (EGF) activates the ALA neuron, which then releases neuropeptides to promote sleep. To further understand this behavior, we established a new model of SIS using irradiation by ultraviolet C (UVC) light. While UVC irradiation requires ALA signaling and leads to a sleep state similar to that induced by heat and other stressors, it does not induce the proteostatic stress seen with heat exposure. Based on the known genotoxic effects of UVC irradiation, we tested two genes, atl-1 and cep-1, which encode proteins that act in the DNA damage response pathway. Loss-of-function mutants of atl-1 had no defect in UVC-induced SIS but a partial loss-of-function mutant of cep-1, gk138, had decreased movement quiescence following UVC irradiation. Germline ablation experiments and tissue-specific RNA interference experiments showed that cep-1 is required somatically in neurons for its effect on SIS. The cep-1(gk138) mutant suppressed body movement quiescence controlled by EGF, indicating that CEP-1 acts downstream or in parallel to ALA activation to promote quiescence in response to ultraviolet light. |
| Volume | 207(2) |
| Pages | 571-582 |
| Published | 2017-10-1 |
| DOI | 10.1534/genetics.117.300070 |
| PII | genetics.117.300070 |
| PMID | 28754659 |
| PMC | PMC5629324 |
| MeSH | Animals Ataxia Telangiectasia Mutated Proteins / genetics Ataxia Telangiectasia Mutated Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Loss of Function Mutation Movement Neurons / metabolism Sleep* Stress, Physiological* Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / metabolism* Ultraviolet Rays* |
| IF | 4.015 |
| Times Cited | 16 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2427 tm853 |