論文 - 詳細
| RRC ID | 51495 |
|---|---|
| 著者 | Shintani T, Sakoguchi H, Yoshihara A, Izumori K, Sato M. |
| タイトル | d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Dietary restriction (DR) is an effective intervention known to increase lifespan in a wide variety of organisms. DR also delays the onset of aging-associated diseases. DR mimetics, compounds that can mimic the effects of DR, have been intensively explored. d-Allulose (d-Alu), the C3-epimer of d-fructose, is a rare sugar that has various health benefits, including anti-hyperglycemia and anti-obesity effects. Here, we report that d-Alu increased the lifespan of Caenorhabditis elegans both under monoxenic and axenic culture conditions. d-Alu did not further extend the lifespan of the long-lived DR model eat-2 mutant, strongly indicating that the effect is related to DR. However, d-Alu did not reduce the food intake of wild-type C. elegans. To explore the mechanisms of the d-Alu longevity effect, we examined the lifespan of d-Alu-treated mutants deficient for nutrient sensing pathway-related genes daf-16, sir-2.1, aak-2, and skn-1. As a result, d-Alu increased the lifespan of the daf-16, sir-2.1, and skn-1 mutants, but not the aak-2 mutant, indicating that the lifespan extension was dependent on the energy sensor, AMP-activated protein kinase (AMPK). d-Alu also enhanced the mRNA expression and enzyme activities of superoxide dismutase (SOD) and catalase. From these findings, we conclude that d-Alu extends lifespan by increasing oxidative stress resistance through a DR mechanism, making it a candidate DR mimetic. |
| 巻・号 | 493(4) |
| ページ | 1528-1533 |
| 公開日 | 2017-12-2 |
| DOI | 10.1016/j.bbrc.2017.09.147 |
| PII | S0006-291X(17)31928-9 |
| PMID | 28965946 |
| MeSH | AMP-Activated Protein Kinases / metabolism Animals Biomimetic Materials / chemistry Biomimetic Materials / pharmacology Caenorhabditis elegans / drug effects* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caloric Restriction / methods* Catalase / genetics Catalase / metabolism Eating / drug effects Eating / genetics Eating / physiology Fructose / chemistry Fructose / pharmacology* Genes, Helminth Longevity / drug effects Longevity / genetics Longevity / physiology Mutation Oxidative Stress / drug effects Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Receptors, Nicotinic / genetics Receptors, Nicotinic / metabolism Stereoisomerism Superoxide Dismutase / genetics Superoxide Dismutase / metabolism |
| IF | 2.985 |
| 引用数 | 11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm4241 |