論文 - 詳細
| RRC ID | 51512 |
|---|---|
| 著者 | Cho I, Song HO, Cho JH. |
| タイトル | Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans. |
| ジャーナル | Mol Cells |
| Abstract |
The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during aging. Uncoupling agents also restored neuronal phenotypes of ucp-4 mutants to those exhibited by wild type, while ucp-4 overexpression attenuated the severity of age-dependent neurodegeneration. Neuronal improvements were further associated with reductions in mitochondrial membrane potentials. However, these age-dependent neuroprotective effects were limited in mitophagy-deficient mutant, pink-1, background. These results suggest that membrane uncoupling can attenuate age-dependent neurodegeneration by stimulating mitophagy. |
| 巻・号 | 40(11) |
| ページ | 864-870 |
| 公開日 | 2017-11-30 |
| DOI | 10.14348/molcells.2017.0172 |
| PII | molcells.2017.0172 |
| PMID | 29081084 |
| PMC | PMC5712516 |
| MeSH | 2,4-Dinitrophenol / pharmacology* 2,4-Dinitrophenol / therapeutic use Aging / genetics* Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Disease Models, Animal Membrane Potential, Mitochondrial / drug effects Mitochondria / drug effects Mitochondria / physiology Mitochondrial Uncoupling Proteins / genetics* Mitochondrial Uncoupling Proteins / metabolism Mitophagy / drug effects Mutation Neurodegenerative Diseases / drug therapy Neurodegenerative Diseases / etiology* Neurodegenerative Diseases / genetics Organophosphonates / pharmacology* Organophosphonates / therapeutic use Piperazines / pharmacology* Piperazines / therapeutic use |
| IF | 4.081 |
| 引用数 | 4 |
| リソース情報 | |
| 線虫 | tm1779 |