Reference - Detail
RRC ID | 51858 |
---|---|
Author | Burdeos GC, Ito J, Eitsuka T, Nakagawa K, Kimura F, Miyazawa T. |
Title | δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling. |
Journal | Food Funct |
Abstract |
Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway. |
Volume | 7(10) |
Pages | 4170-4174 |
Published | 2016-10-12 |
DOI | 10.1039/c6fo00826g |
PMID | 27713963 |
MeSH | Carcinoma, Hepatocellular / metabolism Cell Proliferation / drug effects* Chromans / chemistry Chromans / pharmacology* Extracellular Signal-Regulated MAP Kinases / genetics Extracellular Signal-Regulated MAP Kinases / metabolism Gene Expression Regulation, Enzymologic / drug effects Gene Expression Regulation, Neoplastic / drug effects* Hep G2 Cells Humans Liver Neoplasms / metabolism MAP Kinase Kinase Kinases / genetics MAP Kinase Kinase Kinases / metabolism Signal Transduction / drug effects Vitamin E / analogs & derivatives* Vitamin E / chemistry Vitamin E / pharmacology raf Kinases / genetics raf Kinases / metabolism* ras Proteins / genetics ras Proteins / metabolism* |
IF | 4.171 |
Times Cited | 6 |
Resource | |
Human and Animal Cells | Hep G2(RCB1886) |