| RRC ID |
51875
|
| 著者 |
Izumi Y, Fujii K, Yamamoto S, Matsuo K, Namatame H, Taniguchi M, Yokoya A.
|
| タイトル |
DNA damage response induces structural alterations in histone H3-H4.
|
| ジャーナル |
J Radiat Res
|
| Abstract |
Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A-H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.
|
| 巻・号 |
58(1)
|
| ページ |
59-65
|
| 公開日 |
2017-1-1
|
| DOI |
10.1093/jrr/rrw086
|
| PII |
rrw086
|
| PMID |
27672100
|
| PMC |
PMC5321191
|
| MeSH |
Cell Line, Tumor
Circular Dichroism
DNA Damage*
DNA Repair / radiation effects
Electrophoresis, Polyacrylamide Gel
Histones / chemistry*
Histones / metabolism
Humans
Protein Structure, Secondary
Synchrotrons
X-Rays
|
| IF |
2.014
|
| 引用数 |
6
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa/Fucci(RCB2812) |
