論文 - 詳細
| RRC ID | 52147 |
|---|---|
| 著者 | Hara K, Miyazaki T, Yokobori T, Yoshida T, Kumakura Y, Honjyo H, Sakai M, Sohda M, Fukuchi M, Kuwano H. |
| タイトル | Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND/AIM:We detected microRNA-7 (miR-7) as being specific for oesophageal squamous cell carcinoma (ESCC) by using database analysis. However, the significance of miR-7 in clinical ESCC remains unexplored. This study aimed to clarify the clinicopathological significance of miR-7 in ESCC, and investigate miR-7 function. MATERIALS AND METHODS:Quantitative TaqMan reverse transcription polymerase chain reaction was used to evaluate miR-7 expression in 85 ESCC samples to determine the clinicopathological significance of miR-7 expression. The regulation of proliferation by miR-7 was examined with miR-7 precursor-transfected cells. RESULTS:The expression of miR-7 in ESCC was higher than that in normal tissues. Low expression levels of miR-7 were associated with poor prognosis. Multivariate analysis indicated that low miR-7 expression was an independent prognostic factor for poor survival. In vitro assays showed miR-7 precursor treatment suppressed the proliferation of ESCC cells. CONCLUSION:miR-7 might be a promising prognostic marker and therapeutic target in ESCC. |
| 巻・号 | 37(3) |
| ページ | 1043-1048 |
| 公開日 | 2017-3-1 |
| DOI | 10.21873/anticanres.11415 |
| PII | 37/3/1043 |
| PMID | 28314263 |
| MeSH | Biomarkers, Tumor / metabolism Carcinoma, Squamous Cell / drug therapy Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / metabolism* Cell Line, Tumor Cell Proliferation Down-Regulation Esophageal Neoplasms / drug therapy Esophageal Neoplasms / genetics Esophageal Neoplasms / metabolism* Esophageal Squamous Cell Carcinoma Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans MicroRNAs / metabolism* Multivariate Analysis Prognosis Reverse Transcriptase Polymerase Chain Reaction Treatment Outcome |
| IF | 1.994 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | TE-8(RCB2098) |