RRC ID 52403
Author Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A, Cao L.
Title Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model.
Journal Mol Med Rep
Abstract Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage. Additionally, it lowered the Osteoarthritis Research Society International‑Modified Mankin score and prevented the loss of articular cartilage from Safranin O and Fast Green staining. HF reduced the progression of osteoarthritis by downregulating abnormally elevated TGF‑β1 activity in articular cartilage. Administration of HF may be a potential preventive therapy for OA.
Volume 16(5)
Pages 7679-7684
Published 2017-11-1
DOI 10.3892/mmr.2017.7549
PMID 28944864
MeSH Animals Anterior Cruciate Ligament / drug effects Anterior Cruciate Ligament / metabolism Anterior Cruciate Ligament / pathology Anti-Inflammatory Agents / pharmacology* Cartilage, Articular / drug effects* Cartilage, Articular / metabolism Cartilage, Articular / pathology Collagen Type X / antagonists & inhibitors Collagen Type X / genetics Collagen Type X / metabolism Disease Models, Animal Gene Expression Regulation Male Matrix Metalloproteinase 13 / genetics Matrix Metalloproteinase 13 / metabolism Mice Mice, Inbred C57BL Osteoarthritis / drug therapy* Osteoarthritis / genetics Osteoarthritis / metabolism Osteoarthritis / pathology Piperidines / pharmacology* Quinazolinones / pharmacology* Signal Transduction Transforming Growth Factor beta1 / antagonists & inhibitors Transforming Growth Factor beta1 / genetics* Transforming Growth Factor beta1 / metabolism
IF 2.1
Times Cited 1
Human and Animal Cells ATDC5(RCB0565)