Reference - Detail
| RRC ID | 52710 |
|---|---|
| Author | Charney RM, Forouzmand E, Cho JS, Cheung J, Paraiso KD, Yasuoka Y, Takahashi S, Taira M, Blitz IL, Xie X, Cho KW. |
| Title | Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. |
| Journal | Dev Cell |
| Abstract |
The interplay between transcription factors and chromatin dictates gene regulatory network activity. Germ layer specification is tightly coupled with zygotic gene activation and, in most metazoans, is dependent upon maternal factors. We explore the dynamic genome-wide interactions of Foxh1, a maternal transcription factor that mediates Nodal/TGF-β signaling, with cis-regulatory modules (CRMs) during mesendodermal specification. Foxh1 marks CRMs during cleavage stages and recruits the co-repressor Tle/Groucho in the early blastula. We highlight a population of CRMs that are continuously occupied by Foxh1 and show that they are marked by H3K4me1, Ep300, and Fox/Sox/Smad motifs, suggesting interplay between these factors in gene regulation. We also propose a molecular "hand-off" between maternal Foxh1 and zygotic Foxa at these CRMs to maintain enhancer activation. Our findings suggest that Foxh1 functions at the top of a hierarchy of interactions by marking developmental genes for activation, beginning with the onset of zygotic gene expression. |
| Volume | 40(6) |
| Pages | 595-607.e4 |
| Published | 2017-3-27 |
| DOI | 10.1016/j.devcel.2017.02.017 |
| PII | S1534-5807(17)30086-2 |
| PMID | 28325473 |
| PMC | PMC5434453 |
| MeSH | Animals Blastula / metabolism Cleavage Stage, Ovum / metabolism Co-Repressor Proteins / metabolism Embryo, Nonmammalian / metabolism Endoderm / embryology Endoderm / metabolism* Enhancer Elements, Genetic / genetics Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism* Gene Expression Regulation, Developmental* Genome Histones / metabolism Lysine / metabolism Mesoderm / embryology Mesoderm / metabolism* Methylation Nodal Protein / metabolism Protein Binding / genetics RNA Polymerase II / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism Regulatory Sequences, Nucleic Acid / genetics Sequence Analysis, RNA Signal Transduction / genetics Transcription Factors / metabolism* Transcription, Genetic Xenopus / embryology* Xenopus / genetics* Xenopus / metabolism Xenopus Proteins / genetics Xenopus Proteins / metabolism* |
| IF | 10.092 |
| Times Cited | 20 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Clawed frogs / Newts | Xenopus tropicalis |