論文 - 詳細
| RRC ID | 53250 |
|---|---|
| 著者 | Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A. |
| タイトル | A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. |
| ジャーナル | Cell |
| Abstract |
Multiple division cycles without growth are a characteristic feature of early embryogenesis. The female germline loads proteins and RNAs into oocytes to support these divisions, which lack many quality control mechanisms operating in somatic cells undergoing growth. Here, we describe a small RNA-Argonaute pathway that ensures early embryonic divisions in C. elegans by employing catalytic slicing activity to broadly tune, instead of silence, germline gene expression. Misregulation of one target, a kinesin-13 microtubule depolymerase, underlies a major phenotype associated with pathway loss. Tuning of target transcript levels is guided by the density of homologous small RNAs, whose generation must ultimately be related to target sequence. Thus, the tuning action of a small RNA-catalytic Argonaute pathway generates oocytes capable of supporting embryogenesis. We speculate that the specialized nature of germline chromatin led to the emergence of small RNA-catalytic Argonaute pathways in the female germline as a post-transcriptional control layer to optimize oocyte composition. |
| 巻・号 | 165(2) |
| ページ | 396-409 |
| 公開日 | 2016-4-7 |
| DOI | 10.1016/j.cell.2016.02.040 |
| PII | S0092-8674(16)30190-8 |
| PMID | 27020753 |
| PMC | PMC4826293 |
| MeSH | Animals Argonaute Proteins / metabolism Base Sequence Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cell Division Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism* Embryonic Development Female Kinesins / metabolism Metabolic Networks and Pathways* Microtubules / metabolism Molecular Sequence Data Oocytes / metabolism* RNA Processing, Post-Transcriptional |
| IF | 38.637 |
| 引用数 | 29 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm892 |