論文 - 詳細
| RRC ID | 53264 |
|---|---|
| 著者 | Wei Y, Kenyon C. |
| タイトル | Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
In Caenorhabditis elegans, removing germ cells slows aging and extends life. Here we show that transcription factors that extend life and confer protection to age-related protein-aggregation toxicity are activated early in adulthood in response to a burst of reactive oxygen species (ROS) and a shift in sulfur metabolism. Germline loss triggers H2S production, mitochondrial biogenesis, and a dynamic pattern of ROS in specific somatic tissues. A cytoskeletal protein, KRI-1, plays a key role in the generation of H2S and ROS. These kri-1-dependent redox species, in turn, promote life extension by activating SKN-1/Nrf2 and the mitochondrial unfolded-protein response, respectively. Both H2S and, remarkably, kri-1-dependent ROS are required for the life extension produced by low levels of the superoxide-generator paraquat and by a mutation that inhibits respiration. Together our findings link reproductive signaling to mitochondria and define an inducible, kri-1-dependent redox-signaling module that can be invoked in different contexts to extend life and counteract proteotoxicity. |
| 巻・号 | 113(20) |
| ページ | E2832-41 |
| 公開日 | 2016-5-17 |
| DOI | 10.1073/pnas.1524727113 |
| PII | 1524727113 |
| PMID | 27140632 |
| PMC | PMC4878494 |
| MeSH | Active Transport, Cell Nucleus Aging* Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism DNA-Binding Proteins / metabolism Germ Cells / physiology Hydrogen Sulfide / metabolism* Intracellular Signaling Peptides and Proteins / metabolism Longevity Mitochondrial Dynamics Organelle Biogenesis Oxidation-Reduction Reactive Oxygen Species / metabolism* Signal Transduction Transcription Factors / metabolism |
| IF | 9.412 |
| 引用数 | 43 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1011 tm3676 tm760 |