論文 - 詳細
| RRC ID | 53282 |
|---|---|
| 著者 | Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K. |
| タイトル | Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans. |
| ジャーナル | Arch Biochem Biophys |
| Abstract |
Zinc is an essential metal that is involved in a wide range of biological processes, and aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically similar to zinc, but it is a nonessential environmental pollutant. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. The nematode Caenorhabditis elegans is emerging as a powerful model system to investigate zinc trafficking and homeostasis as well as cadmium toxicity. Here we review genetic and molecular studies that have combined to generate a picture of zinc homeostasis based on the transcriptional control of zinc transporters in intestinal cells. Furthermore, we summarize studies of cadmium toxicity that reveal intriguing parallels with zinc biology. |
| 巻・号 | 611 |
| ページ | 120-133 |
| 公開日 | 2016-12-1 |
| DOI | 10.1016/j.abb.2016.05.021 |
| PII | S0003-9861(16)30185-0 |
| PMID | 27261336 |
| MeSH | Animals Biological Transport Cadmium / physiology* Caenorhabditis elegans / physiology* Cell Lineage Culture Media Diet Dose-Response Relationship, Drug Female Green Fluorescent Proteins / chemistry Homeostasis Male Models, Biological Mutation Phenotype Spermatozoa / physiology Vulva / physiology Zinc / physiology* |
| IF | 3.391 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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