RRC ID 53282
Author Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K.
Title Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans.
Journal Arch. Biochem. Biophys.
Abstract Zinc is an essential metal that is involved in a wide range of biological processes, and aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically similar to zinc, but it is a nonessential environmental pollutant. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. The nematode Caenorhabditis elegans is emerging as a powerful model system to investigate zinc trafficking and homeostasis as well as cadmium toxicity. Here we review genetic and molecular studies that have combined to generate a picture of zinc homeostasis based on the transcriptional control of zinc transporters in intestinal cells. Furthermore, we summarize studies of cadmium toxicity that reveal intriguing parallels with zinc biology.
Volume 611
Pages 120-133
Published 2016-12-1
DOI 10.1016/j.abb.2016.05.021
PII S0003-9861(16)30185-0
PMID 27261336
MeSH Animals Biological Transport Cadmium / physiology* Caenorhabditis elegans / physiology* Cell Lineage Culture Media Diet Dose-Response Relationship, Drug Female Green Fluorescent Proteins / chemistry Homeostasis Male Models, Biological Mutation Phenotype Spermatozoa / physiology Vulva / physiology Zinc / physiology*
IF 3.559
C.elegans NA