論文 - 詳細
| RRC ID | 53330 |
|---|---|
| 著者 | Bohr T, Ashley G, Eggleston E, Firestone K, Bhalla N. |
| タイトル | Synaptonemal Complex Components Are Required for Meiotic Checkpoint Function in Caenorhabditis elegans. |
| ジャーナル | Genetics |
| Abstract |
Synapsis involves the assembly of a proteinaceous structure, the synaptonemal complex (SC), between paired homologous chromosomes, and is essential for proper meiotic chromosome segregation. In Caenorhabditis elegans, the synapsis checkpoint selectively removes nuclei with unsynapsed chromosomes by inducing apoptosis. This checkpoint depends on pairing centers (PCs), cis-acting sites that promote pairing and synapsis. We have hypothesized that the stability of homolog pairing at PCs is monitored by this checkpoint. Here, we report that SC components SYP-3, HTP-3, HIM-3, and HTP-1 are required for a functional synapsis checkpoint. Mutation of these components does not abolish PC function, demonstrating they are bona fide checkpoint components. Further, we identify mutant backgrounds in which the instability of homolog pairing at PCs does not correlate with the synapsis checkpoint response. Altogether, these data suggest that, in addition to homolog pairing, SC assembly may be monitored by the synapsis checkpoint. |
| 巻・号 | 204(3) |
| ページ | 987-997 |
| 公開日 | 2016-11-1 |
| DOI | 10.1534/genetics.116.191494 |
| PII | genetics.116.191494 |
| PMID | 27605049 |
| PMC | PMC5105873 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism Chromosome Pairing* Meiosis* Mutation Synaptonemal Complex / genetics Synaptonemal Complex / metabolism* |
| IF | 4.015 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3655 tm2713 tm1458 tm2543 |