論文 - 詳細
| RRC ID | 53345 |
|---|---|
| 著者 | Piazzesi A, Papić D, Bertan F, Salomoni P, Nicotera P, Bano D. |
| タイトル | Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. |
| ジャーナル | Cell Rep |
| Abstract |
Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here, we study the importance of the histone variant H3.3 in Caenorhabditis elegans longevity pathways. We show that H3.3-deficient nematodes have negligible lifespan differences compared to wild-type animals. However, H3.3 is essential for the lifespan extension of C. elegans mutants in which pronounced transcriptional changes control longevity programs. Notably, H3.3 loss critically affects the expression of a very large number of genes in long-lived nematodes, resulting in transcriptional profiles similar to wild-type animals. We conclude that H3.3 positively contributes to diverse lifespan-extending signaling pathways, with potential implications on age-related processes in multicellular organisms. |
| 巻・号 | 17(4) |
| ページ | 987-996 |
| 公開日 | 2016-10-18 |
| DOI | 10.1016/j.celrep.2016.09.074 |
| PII | S2211-1247(16)31330-4 |
| PMID | 27760329 |
| PMC | PMC5081402 |
| MeSH | Animals Base Sequence Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism DNA Replication / genetics* Gene Expression Regulation, Developmental Histones / genetics Histones / metabolism* Longevity / physiology* Mutation / genetics Survival Analysis Transcription, Genetic* |
| IF | 8.109 |
| 引用数 | 22 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2066 |