Reference - Detail
|Author||Shao LW, Niu R, Liu Y.|
|Title||Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response.|
Neurons have a central role in the systemic coordination of mitochondrial unfolded protein response (UPRmt) and the cell non-autonomous modulation of longevity. However, the mechanism by which the nervous system senses mitochondrial stress and communicates to the distal tissues to induce UPRmt remains unclear. Here we employ the tissue-specific CRISPR-Cas9 approach to disrupt mitochondrial function only in the nervous system of Caenorhabditis elegans, and reveal a cell non-autonomous induction of UPRmt in peripheral cells. We further show that a neural sub-circuit composed of three types of sensory neurons, and one interneuron is required for sensing and transducing neuronal mitochondrial stress. In addition, neuropeptide FLP-2 functions in this neural sub-circuit to signal the non-autonomous UPRmt. Taken together, our results suggest a neuropeptide coordination of mitochondrial stress response in the nervous system.
|MeSH||Animals Animals, Genetically Modified / metabolism CRISPR-Cas Systems / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Gene Targeting Genotype Intestinal Mucosa / metabolism Longevity Mitochondria / metabolism* Molecular Chaperones / genetics Molecular Chaperones / metabolism Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / metabolism Neuropeptides / genetics Neuropeptides / metabolism* Promoter Regions, Genetic RNA Interference Signal Transduction Unfolded Protein Response / physiology* rab3 GTP-Binding Proteins / genetics rab3 GTP-Binding Proteins / metabolism|