RRC ID 53412
Author Yunger E, Safra M, Levi-Ferber M, Haviv-Chesner A, Henis-Korenblit S.
Title Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.
Journal PLoS Genet.
Abstract In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals. Furthermore, irg-7 activation by itself sensitizes the animals' innate immune response and extends the lifespan of animals exposed to live bacteria. This lifespan-extending pathogen resistance relies on the somatic gonad as well as on many genes previously associated with the reproductive longevity pathway. This suggests that these genes are also relevant in animals with an intact gonad, and can affect their resistance to pathogens. Altogether, this study demonstrates the tight association between germline homeostasis and the immune response of animals, and raises the possibility that the reproductive system can act as a signaling center to divert resources towards defending against putative pathogen attacks.
Volume 13(2)
Pages e1006577
Published 2017-2
DOI 10.1371/journal.pgen.1006577
PMID 28196094
PMC PMC5308781
MeSH Aging / genetics Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / immunology Caenorhabditis elegans Proteins / biosynthesis* Caenorhabditis elegans Proteins / genetics* Forkhead Transcription Factors / biosynthesis* Forkhead Transcription Factors / genetics Gene Expression Regulation, Developmental Germ Cells / growth & development Gonads / growth & development Gonads / metabolism Immunity, Innate / genetics* Lectins, C-Type / genetics* Longevity / genetics* Mutation Receptors, Cytoplasmic and Nuclear / biosynthesis* Receptors, Cytoplasmic and Nuclear / genetics Reproduction / genetics Signal Transduction
IF 5.54