RRC ID 53436
著者 Schwieterman AA, Steves AN, Yee V, Donelson CJ, Bentley MR, Santorella EM, Mehlenbacher TV, Pital A, Howard AM, Wilson MR, Ereddia DE, Effrein KS, McMurry JL, Ackley BD, Chisholm AD, Hudson ML.
タイトル The Caenorhabditis elegans Ephrin EFN-4 Functions Non-cell Autonomously with Heparan Sulfate Proteoglycans to Promote Axon Outgrowth and Branching.
ジャーナル Genetics
Abstract The Eph receptors and their cognate ephrin ligands play key roles in many aspects of nervous system development. These interactions typically occur within an individual tissue type, serving either to guide axons to their terminal targets or to define boundaries between the rhombomeres of the hindbrain. We have identified a novel role for the Caenorhabditis elegans ephrin EFN-4 in promoting primary neurite outgrowth in AIY interneurons and D-class motor neurons. Rescue experiments reveal that EFN-4 functions non-cell autonomously in the epidermis to promote primary neurite outgrowth. We also find that EFN-4 plays a role in promoting ectopic axon branching in a C. elegans model of X-linked Kallmann syndrome. In this context, EFN-4 functions non-cell autonomously in the body-wall muscle and in parallel with HS modification genes and HSPG core proteins. This is the first report of an epidermal ephrin providing a developmental cue to the nervous system.
巻・号 202(2)
ページ 639-60
公開日 2016-2-1
DOI 10.1534/genetics.115.185298
PII genetics.115.185298
PMID 26645816
PMC PMC4788240
MeSH Animals Axons / metabolism* Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Cell Line Ephrins / genetics* Ephrins / metabolism* Gene Expression Gene Knock-In Techniques Heparan Sulfate Proteoglycans / metabolism* Humans Interneurons / metabolism Models, Biological Motor Neurons / metabolism Mutation Neurogenesis / genetics Neurons / metabolism Phenotype Receptors, Eph Family / genetics Receptors, Eph Family / metabolism Signal Transduction
IF 4.015
引用数 7
リソース情報
線虫 tm472 tm3056 tm729