論文 - 詳細
| RRC ID | 53458 |
|---|---|
| 著者 | Chi C, Ronai D, Than MT, Walker CJ, Sewell AK, Han M. |
| タイトル | Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans. |
| ジャーナル | Genes Dev |
| Abstract |
Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We established a model system in which nucleotide metabolism is perturbed in both the nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is arrested. We provide evidence that this impact of U/T level on the germline is critically mediated by GLP-1/Notch and MPK-1/MAPK, known to regulate germline mitotic proliferation. This germline defect is suppressed by hyperactivation of glp-1 or disruption of genes downstream from glp-1 to promote meiosis but not by activation of the IIS or TORC1 pathways. Moreover, GLP-1 expression is post-transcriptionally modulated by U/T levels. Our results reveal a previously unknown nucleotide-sensing mechanism for controlling reproductivity. |
| 巻・号 | 30(3) |
| ページ | 307-20 |
| 公開日 | 2016-2-1 |
| DOI | 10.1101/gad.275107.115 |
| PII | 30/3/307 |
| PMID | 26833730 |
| PMC | PMC4743060 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cell Proliferation / genetics Escherichia coli / genetics Fertility / genetics Germ Cells Glucagon-Like Peptide 1 / metabolism* Mutation Nucleotides / metabolism* Receptors, Notch / metabolism* Signal Transduction* |
| IF | 9.527 |
| 引用数 | 21 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm742 |