Reference - Detail
| RRC ID | 53533 |
|---|---|
| Author | Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR. |
| Title | Autophagy-mediated longevity is modulated by lipoprotein biogenesis. |
| Journal | Autophagy |
| Abstract |
Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is not fully understood. Here we report that lipoprotein production, autophagy and lysosomal lipolysis are linked to modulate life span in a conserved fashion. We find that overexpression of the yolk lipoprotein VIT/vitellogenin reduces the life span of long-lived animals by impairing the induction of autophagy-related and lysosomal genes necessary for longevity. Accordingly, reducing vitellogenesis increases life span via induction of autophagy and lysosomal lipolysis. Life-span extension due to reduced vitellogenesis or enhanced lysosomal lipolysis requires nuclear hormone receptors (NHRs) NHR-49 and NHR-80, highlighting novel roles for these NHRs in lysosomal lipid signaling. In dietary-restricted worms and mice, expression of VIT and hepatic APOB (apolipoprotein B), respectively, are significantly reduced, suggesting a conserved longevity mechanism. Altogether, our study demonstrates that lipoprotein biogenesis is an important mechanism that modulates aging by impairing autophagy and lysosomal lipolysis. |
| Volume | 12(2) |
| Pages | 261-72 |
| Published | 2016-1-1 |
| DOI | 10.1080/15548627.2015.1127464 |
| PMID | 26671266 |
| PMC | PMC4836030 |
| MeSH | Animals Autophagy* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Caloric Restriction Gene Expression Regulation Gene Silencing Intestinal Mucosa / metabolism Lipase / metabolism Lipolysis Lipoproteins / biosynthesis* Longevity / physiology* Lysosomes / metabolism Transcription, Genetic Vitellogenesis / genetics Vitellogenins / metabolism |
| IF | 11.059 |
| Times Cited | 43 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 41 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1011 tm4498 tm4417 tm1978 |