RRC ID 53547
著者 Hill VM, O'Connor RM, Sissoko GB, Irobunda IS, Leong S, Canman JC, Stavropoulos N, Shirasu-Hiza M.
タイトル A bidirectional relationship between sleep and oxidative stress in Drosophila.
ジャーナル PLoS Biol
Abstract Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep.
巻・号 16(7)
ページ e2005206
公開日 2018-7-1
DOI 10.1371/journal.pbio.2005206
PII pbio.2005206
PMID 30001323
PMC PMC6042693
MeSH Animals Antioxidants / metabolism Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Gene Expression Regulation Gene Knockdown Techniques Immunity Longevity Mutation / genetics Neurons / metabolism Oxidative Stress* / genetics RNA Interference Reactive Oxygen Species / metabolism Sleep / physiology*
IF 7.076
引用数 25
リソース情報
ショウジョウバエ 11861R-2