| RRC ID |
53547
|
| 著者 |
Hill VM, O'Connor RM, Sissoko GB, Irobunda IS, Leong S, Canman JC, Stavropoulos N, Shirasu-Hiza M.
|
| タイトル |
A bidirectional relationship between sleep and oxidative stress in Drosophila.
|
| ジャーナル |
PLoS Biol
|
| Abstract |
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep.
|
| 巻・号 |
16(7)
|
| ページ |
e2005206
|
| 公開日 |
2018-7-1
|
| DOI |
10.1371/journal.pbio.2005206
|
| PII |
pbio.2005206
|
| PMID |
30001323
|
| PMC |
PMC6042693
|
| MeSH |
Animals
Antioxidants / metabolism
Drosophila Proteins / metabolism
Drosophila melanogaster / genetics
Drosophila melanogaster / physiology*
Gene Expression Regulation
Gene Knockdown Techniques
Immunity
Longevity
Mutation / genetics
Neurons / metabolism
Oxidative Stress* / genetics
RNA Interference
Reactive Oxygen Species / metabolism
Sleep / physiology*
|
| IF |
7.076
|
| 引用数 |
25
|
| リソース情報 |
| ショウジョウバエ |
11861R-2 |
