論文 - 詳細
| RRC ID | 53547 |
|---|---|
| 著者 | Hill VM, O'Connor RM, Sissoko GB, Irobunda IS, Leong S, Canman JC, Stavropoulos N, Shirasu-Hiza M. |
| タイトル | A bidirectional relationship between sleep and oxidative stress in Drosophila. |
| ジャーナル | PLoS Biol |
| Abstract |
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep. |
| 巻・号 | 16(7) |
| ページ | e2005206 |
| 公開日 | 2018-7-1 |
| DOI | 10.1371/journal.pbio.2005206 |
| PII | pbio.2005206 |
| PMID | 30001323 |
| PMC | PMC6042693 |
| MeSH | Animals Antioxidants / metabolism Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Gene Expression Regulation Gene Knockdown Techniques Immunity Longevity Mutation / genetics Neurons / metabolism Oxidative Stress* / genetics RNA Interference Reactive Oxygen Species / metabolism Sleep / physiology* |
| IF | 7.076 |
| 引用数 | 25 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 119 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 11861R-2 |