RRC ID 53919
Author Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ.
Title Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.
Journal Sci Rep
Abstract mice, though hearing thresholds were elevated with age. The elevation of hearing thresholds was associated with deterioration of sensory transduction in inner hair cells and loss of outer hair cell function. Although sensory transduction was retained in outer hair cells, their stereocilia eventually degenerated. These results indicate distinct roles and requirements for Tmc1 and Tmc2 in mature cochlear hair cells.
Volume 8(1)
Pages 12125
Published 2018-8-14
DOI 10.1038/s41598-018-29709-8
PII 10.1038/s41598-018-29709-8
PMID 30108230
PMC PMC6092339
IF 4.122
Resource
DNA material MSM Mouse BAC clone (RDB04214) MSMg01-526L10