論文 - 詳細
| RRC ID | 54589 |
|---|---|
| 著者 | Zhu S, Chen R, Soba P, Jan YN. |
| タイトル | JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. |
| ジャーナル | Development |
| Abstract |
Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning. |
| 巻・号 | 146(8) |
| 公開日 | 2019-4-17 |
| DOI | 10.1242/dev.163592 |
| PII | dev.163592 |
| PMID | 30936183 |
| PMC | PMC6503988 |
| MeSH | Animals Dendrites / metabolism* Drosophila / cytology* Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Ecdysone / metabolism* Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology MAP Kinase Signaling System / genetics MAP Kinase Signaling System / physiology Membrane Proteins / genetics Membrane Proteins / metabolism Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism* Signal Transduction / genetics Signal Transduction / physiology |
| IF | 5.763 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 2275R-1 2262R-1 |