論文 - 詳細
| RRC ID | 54772 |
|---|---|
| 著者 | Fang C, Cai X, Hayashi S, Hao S, Sakiyama H, Wang X, Yang Q, Akira S, Nishiguchi S, Fujiwara N, Tsutsui H, Sheng J. |
| タイトル | Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease. |
| ジャーナル | Biochim Biophys Acta Mol Cell Biol Lipids |
| Abstract |
Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mRNA was not increased in the liver, but increased substantially in the muscles of caffeine-treated mice. Caffeine was found to stimulate IL-6 production in cultured myotubes but not in hepatocytes, adipocytes, or macrophages. The inhibition of p38/MAPK abrogated caffeine-induced IL-6 production in muscle cells. Caffeine failed to improve NAFLD in IL-6 and hepatocyte-specific STAT3 knockout mice, indicating that the IL-6/STAT3 pathway is vital for the hepatoprotective effects of caffeine in NAFLD. The possibility that IL-6/STAT3-mediated hepatic autophagosome induction and hepatocytic oxygen consumption are involved in the anti-NAFLD effects of caffeine cannot be excluded, based on the findings presented here. Our results reveal that caffeine ameliorates NAFLD via crosstalk between muscle IL-6 production and liver STAT3 activation. |
| 巻・号 | 1864(3) |
| ページ | 271-280 |
| 公開日 | 2019-3-1 |
| DOI | 10.1016/j.bbalip.2018.12.003 |
| PII | S1388-1981(18)30370-6 |
| PMID | 30553055 |
| MeSH | Adipocytes / metabolism Animals Caffeine / metabolism Caffeine / pharmacology* Diet, High-Fat Disease Models, Animal Hepatocytes / metabolism Interleukin-6 / metabolism* Interleukin-6 / physiology Lipid Metabolism / physiology Liver / drug effects Liver / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Muscle, Skeletal / drug effects Muscle, Skeletal / metabolism Non-alcoholic Fatty Liver Disease / metabolism* Non-alcoholic Fatty Liver Disease / physiopathology STAT3 Transcription Factor / metabolism Signal Transduction / drug effects |
| IF | 4.402 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |