RRC ID 54776
Author Kosibaty Z, Murata Y, Minami Y, Dai T, Kano J, Matsuoka R, Nakano N, Noguchi M.
Title Cytoplasmic expression of epithelial cell transforming sequence 2 in lung adenocarcinoma and its implications for malignant progression.
Journal Lab. Invest.
Abstract  2 cm in diameter). Cytoplasmic positivity for ECT2 was associated with a poor outcome in terms of both disease-free and overall survival (both P < 0.001), and was an independent prognostic factor for overall survival (P = 0.025). Immunocytochemical staining for P-ECT2(T790) demonstrated cytoplasmic and membrane positivity in Calu-3 cells and scraping cytology specimens. Positive P-ECT2(T790) staining was correlated with cytoplasmic ECT2 expression in 6 of 13 scraped cytology specimens tested. In conclusion, our findings indicate that cytoplasmic ECT2 expression could promote the malignant progression of lung adenocarcinoma and may represent a potent therapeutic target for patients with lung adenocarcinoma.
Volume 99(4)
Pages 551-567
Published 2019-4
DOI 10.1038/s41374-018-0142-4
PII 10.1038/s41374-018-0142-4
PMID 30542068
MeSH Adenocarcinoma of Lung / metabolism* Adenocarcinoma of Lung / pathology Cell Line, Tumor Cytoplasm / chemistry Cytoplasm / metabolism* Disease Progression Disease-Free Survival Female Gene Knockdown Techniques Humans Lung Neoplasms / metabolism* Lung Neoplasms / pathology Male Middle Aged Prognosis Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins / metabolism*
IF 4.263
Human and Animal Cells PC-9(RCB4455) RERF-LC-KJ(RCB1313)