| RRC ID |
55868
|
| 著者 |
Chitturi J, Hung W, Rahman AMA, Wu M, Lim MA, Calarco J, Baran R, Huang X, Dennis JW, Zhen M.
|
| タイトル |
The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C. elegans UBR-1 leads to a specific motor deficit: when adult animals generate reversal movements, A-class motor neurons exhibit synchronized activation, preventing body bending. This motor deficit is rescued by removing GOT-1, a transaminase that converts aspartate to glutamate. Both UBR-1 and GOT-1 are expressed and critically required in premotor interneurons of the reversal motor circuit to regulate the motor pattern. ubr-1 and got-1 mutants exhibit elevated and decreased glutamate level, respectively. These results raise an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling.
|
| 巻・号 |
14(4)
|
| ページ |
e1007303
|
| 公開日 |
2018-4-1
|
| DOI |
10.1371/journal.pgen.1007303
|
| PII |
PGENETICS-D-17-02069
|
| PMID |
29649217
|
| PMC |
PMC5931689
|
| MeSH |
Animals
Caenorhabditis elegans / enzymology
Caenorhabditis elegans / genetics
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins
Glutamic Acid / metabolism*
Motor Neurons / physiology
Movement*
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism*
|
| IF |
5.224
|
| 引用数 |
1
|
| リソース情報 |
| 線虫 |
tm2311
tm3424
tm2997
tm3233
tm3788
tm4283 |
