RRC ID 56092
著者 Miyatake Y, Yamano T, Hanayama R.
タイトル Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes.
ジャーナル J Immunol
Abstract During inflammation, phagocytes release digestive enzymes from lysosomes to degrade harmful cells such as pathogens and tumor cells. However, the molecular mechanisms regulating this process are poorly understood. In this study, we identified myoferlin as a critical regulator of lysosomal exocytosis by mouse phagocytes. Myoferlin is a type II transmembrane protein with seven C2 domains in the cytoplasmic region. It localizes to lysosomes and mediates their fusion with the plasma membrane upon calcium stimulation. Myoferlin promotes the release of lysosomal contents, including hydrolytic enzymes, which increase cytotoxicity. These data demonstrate myoferlin's critical role in lysosomal exocytosis by phagocytes, providing novel insights into the mechanisms of inflammation-related cellular injuries.
巻・号 201(10)
ページ 3051-3057
公開日 2018-11-15
DOI 10.4049/jimmunol.1800268
PII jimmunol.1800268
PMID 30333125
MeSH Animals Cytotoxicity, Immunologic / immunology* Exocytosis / immunology Lysosomes / immunology Lysosomes / metabolism* Membrane Proteins / immunology Membrane Proteins / metabolism* Mice Mice, Inbred C57BL Muscle Proteins / immunology Muscle Proteins / metabolism* NIH 3T3 Cells Phagocytes / immunology Phagocytes / metabolism*
IF 4.718
リソース情報
ヒト・動物細胞 NIH3T3