RRC ID 5620
Author Mishima Y, Abreu-Goodger C, Staton AA, Stahlhut C, Shou C, Cheng C, Gerstein M, Enright AJ, Giraldez AJ.
Title Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization.
Journal Genes Dev.
Abstract 54% of the miRNA-mediated regulation in the muscle. We also found that muscle miRNA targets (1) tend to be expressed at low levels in wild-type muscle but are more highly expressed in dicer mutant muscle, and (2) are enriched for actin-related and actin-binding proteins. Loss of dicer function or down-regulation of miR-1 and miR-133 alters muscle gene expression and disrupts actin organization during sarcomere assembly. These results suggest that miR-1 and miR-133 actively shape gene expression patterns in muscle tissue, where they regulate sarcomeric actin organization.
Volume 23(5)
Pages 619-32
Published 2009-3-1
DOI 10.1101/gad.1760209
PII gad.1760209
PMID 19240126
PMC PMC2658521
MeSH Actins / metabolism* Animals Gene Expression Regulation, Developmental* Gene Knockdown Techniques MicroRNAs / metabolism* Muscle, Skeletal / metabolism* Mutation RNA, Messenger / metabolism Reproducibility of Results Sarcomeres / metabolism* Zebrafish / embryology* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism
IF 9.462
Times Cited 87
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