論文 - 詳細
| RRC ID | 56231 |
|---|---|
| 著者 | Verma S, Jagtap U, Goyala A, Mukhopadhyay A. |
| タイトル | A novel gene-diet pair modulates C. elegans aging. |
| ジャーナル | PLoS Genet |
| Abstract |
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging. |
| 巻・号 | 14(8) |
| ページ | e1007608 |
| 公開日 | 2018-8-1 |
| DOI | 10.1371/journal.pgen.1007608 |
| PII | PGENETICS-D-17-01992 |
| PMID | 30125273 |
| PMC | PMC6117094 |
| MeSH | Aging / genetics* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Diet* Gene Expression Regulation Longevity Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / physiology* RNA, Helminth / genetics Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / physiology Signal Transduction Transcriptome p38 Mitogen-Activated Protein Kinases / physiology |
| IF | 5.224 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3036 |