RRC ID 56249
Author Zhao T, Hao Y, Kaplan JM.
Title Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans.
Journal Genetics
Abstract and that oxidative phosphorylation, but not mitochondrial calcium uptake, is required for secretion. Oxidative phosphorylation produces cellular ATP, reactive oxygen species, and consumes oxygen. Disrupting any of these functions could inhibit neuropeptide secretion. We show that blocking mitochondria transport into axons or decreasing mitochondrial function inhibits neuropeptide secretion through activation of the hypoxia inducible factor HIF-1 Our results suggest that axonal mitochondria modulate neuropeptide secretion by regulating transcriptional responses induced by metabolic stress.
Volume 210(1)
Pages 275-285
Published 2018-9
DOI 10.1534/genetics.118.301014
PII genetics.118.301014
PMID 30049781
IF 4.075
Resource
C.elegans tm6026 tm5782 tm776 tm760 tm1146