論文 - 詳細
| RRC ID | 5690 |
|---|---|
| 著者 | Katsuki T, Ailani D, Hiramoto M, Hiromi Y. |
| タイトル | Intra-axonal patterning: intrinsic compartmentalization of the axonal membrane in Drosophila neurons. |
| ジャーナル | Neuron |
| Abstract |
In the developing nervous system, distribution of membrane molecules, particularly axon guidance receptors, is often restricted to specific segments of axons. Such localization of membrane molecules can be important for the formation and function of neural networks; however, how this patterning within axons is achieved remains elusive. Here we show that Drosophila neurons in culture establish intra-axonal patterns in a cell-autonomous manner; several membrane molecules localize to either proximal or distal axon segments without cell-cell contacts. This distinct patterning of membrane proteins is not explained by a simple temporal control of expression, and likely involves spatially controlled vesicular targeting or retrieval. Mobility of transmembrane molecules is restricted at the boundary of intra-axonal segments, indicating that the axonal membrane is compartmentalized by a barrier mechanism. We propose that this intra-axonal compartmentalization is an intrinsic property of Drosophila neurons that provides a basis for the structural and functional development of the nervous system. |
| 巻・号 | 64(2) |
| ページ | 188-99 |
| 公開日 | 2009-10-29 |
| DOI | 10.1016/j.neuron.2009.08.019 |
| PII | S0896-6273(09)00631-X |
| PMID | 19874787 |
| MeSH | Animals Animals, Genetically Modified Axons / physiology* Axons / ultrastructure* Body Patterning / genetics Body Patterning / physiology* Cell Membrane / physiology* Cell Movement / genetics Cell Movement / physiology Cells, Cultured Drosophila / cytology Drosophila Proteins / genetics Dynamins / metabolism Embryo, Nonmammalian Endocytosis / genetics Endocytosis / physiology Gene Expression Regulation, Developmental / physiology Green Fluorescent Proteins / genetics Membrane Proteins / genetics Membrane Proteins / metabolism Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Neurons / cytology* Protein Transport / physiology |
| IF | 14.415 |
| 引用数 | 34 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |