論文 - 詳細
| RRC ID | 57136 |
|---|---|
| 著者 | Aydogan MG, Wainman A, Saurya S, Steinacker TL, Caballe A, Novak ZA, Baumbach J, Muschalik N, Raff JW. |
| タイトル | A homeostatic clock sets daughter centriole size in flies. |
| ジャーナル | J Cell Biol |
| Abstract |
Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4 (Plk4) recruits Ana2/STIL and Sas-6 to the side of an existing "mother" centriole. These two proteins then assemble into a cartwheel, which grows outwards to form the structural core of a new daughter. Here, we show that in early Drosophila melanogaster embryos, daughter centrioles grow at a linear rate during early S-phase and abruptly stop growing when they reach their correct size in mid- to late S-phase. Unexpectedly, the cartwheel grows from its proximal end, and Plk4 determines both the rate and period of centriole growth: the more active the centriolar Plk4, the faster centrioles grow, but the faster centriolar Plk4 is inactivated and growth ceases. Thus, Plk4 functions as a homeostatic clock, establishing an inverse relationship between growth rate and period to ensure that daughter centrioles grow to the correct size. |
| 巻・号 | 217(4) |
| ページ | 1233-1248 |
| 公開日 | 2018-4-2 |
| DOI | 10.1083/jcb.201801014 |
| PII | jcb.201801014 |
| PMID | 29500190 |
| PMC | PMC5881511 |
| MeSH | Animals Behavior, Animal Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Centrioles / enzymology* Centrioles / genetics Circadian Rhythm Signaling Peptides and Proteins / genetics Circadian Rhythm Signaling Peptides and Proteins / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / embryology Drosophila melanogaster / enzymology* Drosophila melanogaster / genetics Embryo, Nonmammalian / enzymology Homeostasis Locomotion Microtubule-Associated Proteins / genetics Microtubule-Associated Proteins / metabolism Mutation Protein Binding Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Protein Transport S Phase* Signal Transduction Time Factors |
| IF | 8.891 |
| 引用数 | 24 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 115 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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