論文 - 詳細
| RRC ID | 57150 |
|---|---|
| 著者 | Nagy O, Nuez I, Savisaar R, Peluffo AE, Yassin A, Lang M, Stern DL, Matute DR, David JR, Courtier-Orgogozo V. |
| タイトル | Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change. |
| ジャーナル | Curr Biol |
| Abstract |
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT. |
| 巻・号 | 28(21) |
| ページ | 3450-3457.e13 |
| 公開日 | 2018-11-5 |
| DOI | 10.1016/j.cub.2018.08.047 |
| PII | S0960-9822(18)31131-X |
| PMID | 30344115 |
| PMC | PMC7385753 |
| MeSH | Animals Binding Sites Biological Evolution* Drosophila / anatomy & histology* Drosophila / genetics* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Evolution, Molecular Gene Expression Regulation, Developmental* Genitalia, Male / anatomy & histology Homeodomain Proteins / genetics* Homeodomain Proteins / metabolism Male Mutation Nucleotides / genetics |
| IF | 9.193 |
| 引用数 | 17 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 72 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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