| RRC ID |
57334
|
| Author |
Robin M, Issa AR, Santos CC, Napoletano F, Petitgas C, Chatelain G, Ruby M, Walter L, Birman S, Domingos PM, Calvi BR, Mollereau B.
|
| Title |
Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.
|
| Journal |
Autophagy
|
| Abstract |
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and mortality in response to oxidative stress compared with wild-type flies. Moreover, autophagy and apoptosis were differentially regulated by the p53 (p53B) and ΔNp53 (p53A) isoforms: while the former induced autophagy in differentiated neurons, which protected against cell death, the latter inhibited autophagy by activating the caspases Dronc, Drice, and Dcp-1. Our results demonstrate that the differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress.
|
| Volume |
15(5)
|
| Pages |
771-784
|
| Published |
2019-5-1
|
| DOI |
10.1080/15548627.2018.1558001
|
| PMID |
30563404
|
| PMC |
PMC6526837
|
| MeSH |
Animals
Animals, Genetically Modified
Apoptosis / genetics*
Autophagy / genetics*
Cells, Cultured
Drosophila melanogaster / genetics*
Drosophila melanogaster / physiology
Oxidative Stress / physiology*
Protein Isoforms / genetics
Protein Isoforms / physiology
Signal Transduction / genetics
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / physiology*
|
| IF |
11.059
|
| Times Cited |
5
|
| Resource |
| Drosophila |
|
