Reference - Detail
| RRC ID | 58158 |
|---|---|
| Author | Wu C, Li Z, Ding X, Guo X, Sun Y, Wang X, Hu Y, Li T, La X, Li J, Li JA, Li W, Xue L. |
| Title | Snail modulates JNK-mediated cell death in Drosophila. |
| Journal | Cell Death Dis |
| Abstract |
Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been extensively studied, its down-stream regulators and the underlying mechanisms remain largely elusive. From a Drosophila genetic screen, we identified Snail (Sna), a Zinc-finger transcription factor, as a novel modulator of ectopic Egr-induced JNK-mediated cell death. In addition, sna is essential for the physiological function of JNK signaling in development. Our genetic epistasis data suggest that Sna acts downstream of JNK to promote cell death. Mechanistically, JNK signaling triggers dFoxO-dependent transcriptional activation of sna. Thus, our findings not only reveal a novel function and the underlying mechanism of Sna in modulating JNK-mediated cell death, but also provide a potential drug target and therapeutic strategies for JNK signaling-related diseases. |
| Volume | 10(12) |
| Pages | 893 |
| Published | 2019-11-26 |
| DOI | 10.1038/s41419-019-2135-7 |
| PII | 10.1038/s41419-019-2135-7 |
| PMID | 31772150 |
| PMC | PMC6879600 |
| MeSH | Animals Apoptosis* Drosophila Proteins / metabolism Drosophila melanogaster / cytology* Drosophila melanogaster / embryology Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Eye / cytology Eye / metabolism Genes, Dominant Genetic Testing JNK Mitogen-Activated Protein Kinases / metabolism* Larva / metabolism MAP Kinase Signaling System Phenotype Snail Family Transcription Factors / genetics Snail Family Transcription Factors / metabolism* Transcription, Genetic Wings, Animal / cytology Wings, Animal / metabolism |
| IF | 6.304 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 4889R-4 3758R-1 3758R-5 |