RRC ID 59483
Author Dues DJ, Andrews EK, Senchuk MM, Van Raamsdonk JM.
Title Resistance to Stress Can Be Experimentally Dissociated From Longevity.
Journal J Gerontol A Biol Sci Med Sci
Abstract On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In this work, we use a genetic approach to disrupt different stress response pathways and examine the resulting effect on the longevity of the long-lived insulin-like growth factor 1 (IGF1) receptor mutant daf-2. Although mutation of the heat shock factor gene hsf-1, deletion of sod genes, deletion of the p38 MAPK kinase gene pmk-1, or deletion of the transcription factor gene egl-27 all resulted in decreased resistance to at least one form of stress and decreased lifespan, the magnitude of change in stress resistance did not correspond to the magnitude of change in lifespan. In addition, we found that deletion of the glycerol-3-phosphate dehydrogenase genes gpdh-1 and gpdh-2 or deletion of the DAF-16 cofactor gene nhl-1 also results in decreased resistance to at least one form of stress but increases lifespan. Overall, our results suggest that while increased stress resistance is associated with longevity, stress resistance, and lifespan can be experimentally dissociated.
Volume 74(8)
Pages 1206-1214
Published 2019-7-12
DOI 10.1093/gerona/gly213
PII 5104783
PMID 30247515
PMC PMC6625593
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism Gene Expression Profiling Glycerolphosphate Dehydrogenase / metabolism Longevity / genetics* Mitogen-Activated Protein Kinases / metabolism Mutation Nerve Tissue Proteins / metabolism Receptor, IGF Type 1 / metabolism Stress, Physiological / genetics* Superoxide Dismutase / metabolism Transcription Factors / metabolism
IF 5.236
Times Cited 3
C.elegans tm783 tm760 tm1146