| RRC ID |
59575
|
| 著者 |
Posner R, Toker IA, Antonova O, Star E, Anava S, Azmon E, Hendricks M, Bracha S, Gingold H, Rechavi O.
|
| タイトル |
Neuronal Small RNAs Control Behavior Transgenerationally.
|
| ジャーナル |
Cell
|
| Abstract |
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.
|
| 巻・号 |
177(7)
|
| ページ |
1814-1826.e15
|
| 公開日 |
2019-6-13
|
| DOI |
10.1016/j.cell.2019.04.029
|
| PII |
S0092-8674(19)30448-9
|
| PMID |
31178120
|
| PMC |
PMC6579485
|
| MeSH |
Animals
Argonaute Proteins / genetics
Argonaute Proteins / metabolism
Behavior, Animal*
Caenorhabditis elegans* / cytology
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
Neurons / cytology
Neurons / metabolism*
RNA, Helminth* / biosynthesis
RNA, Helminth* / genetics
RNA, Small Untranslated* / biosynthesis
RNA, Small Untranslated* / genetics
|
| IF |
36.216
|
| 引用数 |
25
|
| リソース情報 |
| 線虫 |
tm1200
tm1860 |
