論文 - 詳細
| RRC ID | 59575 |
|---|---|
| 著者 | Posner R, Toker IA, Antonova O, Star E, Anava S, Azmon E, Hendricks M, Bracha S, Gingold H, Rechavi O. |
| タイトル | Neuronal Small RNAs Control Behavior Transgenerationally. |
| ジャーナル | Cell |
| Abstract |
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally. |
| 巻・号 | 177(7) |
| ページ | 1814-1826.e15 |
| 公開日 | 2019-6-13 |
| DOI | 10.1016/j.cell.2019.04.029 |
| PII | S0092-8674(19)30448-9 |
| PMID | 31178120 |
| PMC | PMC6579485 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Behavior, Animal* Caenorhabditis elegans* / cytology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Neurons / cytology Neurons / metabolism* RNA, Helminth* / biosynthesis RNA, Helminth* / genetics RNA, Small Untranslated* / biosynthesis RNA, Small Untranslated* / genetics |
| IF | 36.216 |
| 引用数 | 25 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1100 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1200 tm1860 |