RRC ID 59575
Author Posner R, Toker IA, Antonova O, Star E, Anava S, Azmon E, Hendricks M, Bracha S, Gingold H, Rechavi O.
Title Neuronal Small RNAs Control Behavior Transgenerationally.
Journal Cell
Abstract It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.
Volume 177(7)
Pages 1814-1826.e15
Published 2019-6-13
DOI 10.1016/j.cell.2019.04.029
PII S0092-8674(19)30448-9
PMID 31178120
PMC PMC6579485
MeSH Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Behavior, Animal* Caenorhabditis elegans* / cytology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Neurons / cytology Neurons / metabolism* RNA, Helminth* / biosynthesis RNA, Helminth* / genetics RNA, Small Untranslated* / biosynthesis RNA, Small Untranslated* / genetics
IF 36.216
Times Cited 25
C.elegans tm1200 tm1860