Reference - Detail
|Author||Schmeisser S, Li S, Bouchard B, Ruiz M, Des Rosiers C, Roy R.|
|Title||Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling.|
A growing body of evidence suggests that changes in fat metabolism may have a significant effect on lifespan. Accumulation of lipid deposits in non-adipose tissue appears to be critical for age-related pathologies and may also contribute to the aging process itself. We established a model of lipid storage in muscle cells of C. elegans to reveal a mechanism that promotes longevity non-cell-autonomously. Here, we describe how muscle-specific activation of adipose triglyceride lipase (ATGL) and the phospholipase A2 (PLA2) ortholog IPLA-7 collectively affect inter-tissular communication and systemic adaptation that requires the activity of AMP-dependent protein kinase (AMPK) and a highly conserved nuclear receptor outside of the muscle. Our data suggest that muscle-specific bioactive lipid signals, or "lipokines," are generated following triglyceride breakdown and that these signals impinge on a complex network of genes that modify the global lipidome, consequently extending the lifespan.
|MeSH||Adenylate Kinase / metabolism Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Diet Enzyme Activation Hydrolysis Lipid Droplets / metabolism Lipidomics* Lipids / chemistry* Lipolysis Longevity / physiology* Muscle Cells / metabolism Muscles / metabolism* Organ Specificity Transcription Factors / metabolism|