論文 - 詳細
| RRC ID | 59933 |
|---|---|
| 著者 | Akieda Y, Ogamino S, Furuie H, Ishitani S, Akiyoshi R, Nogami J, Masuda T, Shimizu N, Ohkawa Y, Ishitani T. |
| タイトル | Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo. |
| ジャーナル | Nat Commun |
| Abstract |
Morphogen signalling forms an activity gradient and instructs cell identities in a signalling strength-dependent manner to pattern developing tissues. However, developing tissues also undergo dynamic morphogenesis, which may produce cells with unfit morphogen signalling and consequent noisy morphogen gradients. Here we show that a cell competition-related system corrects such noisy morphogen gradients. Zebrafish imaging analyses of the Wnt/β-catenin signalling gradient, which acts as a morphogen to establish embryonic anterior-posterior patterning, identify that unfit cells with abnormal Wnt/β-catenin activity spontaneously appear and produce noise in the gradient. Communication between unfit and neighbouring fit cells via cadherin proteins stimulates apoptosis of the unfit cells by activating Smad signalling and reactive oxygen species production. This unfit cell elimination is required for proper Wnt/β-catenin gradient formation and consequent anterior-posterior patterning. Because this gradient controls patterning not only in the embryo but also in adult tissues, this system may support tissue robustness and disease prevention. |
| 巻・号 | 10(1) |
| ページ | 4710 |
| 公開日 | 2019-10-17 |
| DOI | 10.1038/s41467-019-12609-4 |
| PII | 10.1038/s41467-019-12609-4 |
| PMID | 31624259 |
| PMC | PMC6797755 |
| MeSH | Animals Animals, Genetically Modified Apoptosis / genetics Body Patterning / genetics* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / embryology Embryo, Nonmammalian / metabolism* Gene Expression Regulation, Developmental* Microscopy, Fluorescence Morphogenesis / genetics* Time-Lapse Imaging / methods Wnt Signaling Pathway / genetics* Zebrafish Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism beta Catenin / genetics* beta Catenin / metabolism |
| IF | 11.878 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 64 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(6xTcf/LefBS-miniP:d2EGFP) Tg(6xTcf/LefBS-miniP:Eluc-CP) |