| RRC ID |
60087
|
| Author |
Horstick EJ, Bayleyen Y, Burgess HA.
|
| Title |
Molecular and cellular determinants of motor asymmetry in zebrafish.
|
| Journal |
Nat Commun
|
| Abstract |
Asymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the habenular commissure. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that haploinsufficiency for genes in a core developmental pathway destabilizes left/right identity.
|
| Volume |
11(1)
|
| Pages |
1170
|
| Published |
2020-3-3
|
| DOI |
10.1038/s41467-020-14965-y
|
| PII |
10.1038/s41467-020-14965-y
|
| PMID |
32127541
|
| PMC |
PMC7054361
|
| MeSH |
Animals
Animals, Genetically Modified
Diencephalon / physiology
Eye Proteins / genetics
Habenula / physiology
Larva / physiology
Motor Activity / physiology*
Mutation
Neurons / physiology*
Phototaxis
Receptors, Notch / metabolism
Reflex, Startle
Ubiquitin-Protein Ligases / genetics
Zebrafish / physiology*
Zebrafish Proteins / genetics
|
| IF |
11.878
|
| Times Cited |
1
|
| Resource |
| Zebrafish |
Tg(vglut2a:lRl-Gal4) |
