論文 - 詳細
| RRC ID | 6059 |
|---|---|
| 著者 | Chartoumpekis D, Ziros PG, Psyrogiannis A, Kyriazopoulou V, Papavassiliou AG, Habeos IG. |
| タイトル | Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
The beneficial effects of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase inhibitors (statins) have been attributed not only to their cholesterol lowering effect but also to their pleiotropic actions and especially to their anti-oxidant activity. Nrf2 (NF-E2-related factor 2) is a transcription factor that orchestrates the transcriptional response of cells to oxidative stressors and electrophilic xenobiotics. In this study, primary mouse embryonic fibroblasts from wild type or Nrf2 knock out C57BL6J mice and ST-2 cells were used to investigate the implication of Nrf2 in the mediation of the anti-oxidant effects of statins and the possible involvement of PI3K/Akt pathway in this process. We show for the first time that simvastatin lowers reactive oxygen species (ROS) by activating Nrf2 through the PI3K/Akt pathway. |
| 巻・号 | 396(2) |
| ページ | 463-6 |
| 公開日 | 2010-5-28 |
| DOI | 10.1016/j.bbrc.2010.04.117 |
| PII | S0006-291X(10)00797-7 |
| PMID | 20417615 |
| MeSH | Animals Cell Line Glucose Oxidase / metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Mice Mice, Knockout NF-E2-Related Factor 2 / biosynthesis* NF-E2-Related Factor 2 / genetics Oxidative Stress / drug effects Phosphatidylinositol 3-Kinases / metabolism* Proto-Oncogene Proteins c-akt / metabolism* Reactive Oxygen Species / antagonists & inhibitors* Simvastatin / pharmacology* |
| IF | 2.985 |
| 引用数 | 39 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 実験動物マウス | RBRC01390 |