論文 - 詳細
| RRC ID | 6074 |
|---|---|
| 著者 | Takeo S, Hawley RS, Aigaki T. |
| タイトル | Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. |
| ジャーナル | Dev Biol |
| Abstract |
Ca(2+) signaling pathways play important roles to complete meiosis from metaphase II arrest in vertebrate oocytes. However, less is known about the molecular mechanism of completion of meiosis in Drosophila females. Here, we provide direct evidence that calcineurin, a Ca(2+)/calmodulin (CaM)-dependent phosphatase, is essential for meiotic progression beyond metaphase I in Drosophila oocytes. Oocytes from germline clones lacking CanB2, a calcineurin regulatory subunit B, failed to complete meiosis after egg activation, and laid eggs exhibited a meiotic arrested anaphase I chromosome configuration. Genetic analyses suggest that calcineurin activity is regulated by Sarah (Sra), a family member of regulators of calcineurin (RCANs), through a Sra phosphorylation-dependent mechanism. Our results support a view in which the phosphorylation of Sra not only acts to relieve the inhibitory effects of Sra, but also acts to activate calcineurin, thus explaining the role of RCAN proteins as positive regulators of calcineurin. |
| 巻・号 | 344(2) |
| ページ | 957-67 |
| 公開日 | 2010-8-15 |
| DOI | 10.1016/j.ydbio.2010.06.011 |
| PII | S0012-1606(10)00831-6 |
| PMID | 20561515 |
| MeSH | Anaphase Animals Calcineurin / genetics Calcineurin / metabolism* Chromosomes / metabolism Drosophila / genetics* Drosophila / metabolism* Female Fertilization / genetics Meiosis Metaphase Oocytes / metabolism Oocytes / physiology Phosphoric Monoester Hydrolases / genetics Phosphoric Monoester Hydrolases / metabolism Phosphorylation Signal Transduction / genetics Signal Transduction / physiology |
| IF | 2.896 |
| 引用数 | 37 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109861 DGRC#109863 |