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Species Resource Title
C.elegans tm2371 , tm4791 , tm445 , tm1888 , tm2560 , tm544 Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling.
DNA material pCAG-mSpata33-PA (RDB19398) , pCAG-mSpata33 (P79A)-PA (RDB19399) , pCAG-mSpata33 (I81A)-PA (RDB19400) , pCAG-mSpata33 (I83A)-PA (RDB19401) , pCAG-hSPATA33-8xHIS-1D4 (RDB19402) , pCAG-hPPP3CA-FLAG (RDB19403) , pCAG-hPPP3CB-FLAG (RDB19404) , pCAG-hPPP3R1 (RDB19405) SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.
DNA material pCAG-mPpp3cc-FLAG-6XHIS (RDB19406) , pCAG-mPpp3r2 (RDB19407) , pCAG-hPPP3CC-FLAG (RDB19408) , pCAG-hPPP3R2 (RDB19409) Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
Human and Animal Cells 293(RCB1637) Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.
C.elegans tm3716 A calcineurin homologous protein is required for sodium-proton exchange events in the C. elegans intestine.
C.elegans tm1925 , tm2021 , tm2869 Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans.
C.elegans tm3716 Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans.
Human and Animal Cells BeWo Placenta-specific miRNA (miR-512-3p) targets PPP3R1 encoding the calcineurin B regulatory subunit in BeWo cells.
Yeast NA Functionally redundant protein phosphatase genes PTP2 and MSG5 co-regulate the calcium signaling pathway in Saccharomyces cerevisiae upon exposure to high extracellular calcium concentration.
Drosophila DGRC#109861 , DGRC#109863 The calcineurin regulator sra plays an essential role in female meiosis in Drosophila.
Drosophila DGRC#109861 , DGRC#109863 Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.
C.elegans tm501 Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans.
Yeast HM123 , FY17634(KP898) , FY17635(KP907) , FY17636(KP909) , FY17637(KP1378) , FY14017 , FY14018 Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.
Yeast HM123 Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.