論文 - 詳細
| RRC ID | 60782 |
|---|---|
| 著者 | Lin KY, Wang WD, Lin CH, Rastegari E, Su YH, Chang YT, Liao YF, Chang YC, Pi H, Yu BY, Chen SH, Lin CY, Lu MY, Su TY, Tzou FY, Chan CC, Hsu HJ. |
| タイトル | Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. |
| ジャーナル | Nat Commun |
| Abstract |
Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of Piwi expression in the young niche mimics the aged niche, causing retrotransposon depression and coincident activation of Toll-mediated signaling, which promotes Glycogen synthase kinase 3 activity to degrade β-catenin. Disruption of β-catenin-E-cadherin-mediated GSC anchorage then results in GSC loss. Knocking down gypsy (a highly active retrotransposon) or toll, or inhibiting reverse transcription in the piwi-deficient niche, suppresses GSK3 activity and β-catenin degradation, restoring GSC-niche attachment. This retrotransposon-mediated impairment of aged stem cell maintenance may have relevance in many tissues, and could represent a viable therapeutic target for aging-related tissue degeneration. |
| 巻・号 | 11(1) |
| ページ | 3147 |
| 公開日 | 2020-6-19 |
| DOI | 10.1038/s41467-020-16858-6 |
| PII | 10.1038/s41467-020-16858-6 |
| PMID | 32561720 |
| PMC | PMC7305233 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism* Cadherins / metabolism Cellular Senescence* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Female Gene Silencing Germ Cells / metabolism* Glycogen Synthase Kinase 3 / metabolism Ovary / cytology Ovary / metabolism Retroelements / genetics Signal Transduction Stem Cell Niche / physiology Stem Cells / metabolism Toll-Like Receptors / metabolism beta Catenin / metabolism |
| IF | 12.121 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | Canton S |