| RRC ID |
60951
|
| Author |
Zhang M, Nagaosa K, Nakai Y, Yasugi T, Kushihiki M, Rahmatika D, Sato M, Shiratsuchi A, Nakanishi Y.
|
| Title |
Role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
|
| Journal |
Genes Cells
|
| Abstract |
Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a Drosophila model, in which neoplastic transformation was induced through the simultaneous inhibition of cell-cycle checkpoints and apoptosis. We first determined the location of hemocytes, blood cells of Drosophila playing a role of immune cells, in neoplasia-induced and normal larvae, but there was no significant difference between the two groups. When gene expression pattern in larval hemocytes was determined, the expression of immunity-related genes including those necessary for phagocytosis was reduced in the neoplasia model. We then asked the involvement of phagocytosis in the prevention of neoplasia examining animals where the expression of engulfment receptors instead of apoptosis was retarded. We found that the inhibition of engulfment receptor expression augmented the occurrence of neoplasia induced by a defect in cell-cycle checkpoints. This suggested a role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
|
| Volume |
25(10)
|
| Pages |
675-684
|
| Published |
2020-10-1
|
| DOI |
10.1111/gtc.12804
|
| PMID |
32865275
|
| MeSH |
Animals
Apoptosis / immunology
Cell Line
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / immunology*
Cell Transformation, Neoplastic / metabolism*
Drosophila melanogaster / genetics
Drosophila melanogaster / immunology
Drosophila melanogaster / metabolism
Female
Hemocytes / cytology
Hemocytes / immunology
Hemocytes / metabolism
Larva / metabolism
Male
Neoplasms / genetics
Neoplasms / immunology
Phagocytosis / genetics
Phagocytosis / immunology*
Phagocytosis / physiology
|
| IF |
1.655
|
| Resource |
| Drosophila |
1762R-1 |
