RRC ID 61126
Author Otsuki N, Homma T, Fujiwara H, Kaneko K, Hozumi Y, Shichiri M, Takashima M, Ito J, Konno T, Kurahashi T, Yoshida Y, Goto K, Fujii S, Fujii J.
Title Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.
Journal Regul Toxicol Pharmacol
Abstract Trichloroethylene (TCE) has been implicated as a causative agent for Parkinson's disease (PD). The administration of TCE to rodents induces neurotoxicity associated with dopaminergic neuron death, and evidence suggests that oxidative stress as a major player in the progression of PD. Here we report on TCE-induced behavioral abnormality in mice that are deficient in superoxide dismutase 1 (SOD1). Wild-type (WT) and SOD1-deficient (Sod1(-/-)) mice were intraperitoneally administered TCE (500 mg/kg) over a period of 4 weeks. Although the TCE-administrated Sod1(-/-) mice showed marked abnormal motor behavior, no significant differences were observed among the experimental groups by biochemical and histopathological analyses. However, treating mouse neuroblastoma-derived NB2a cells with TCE resulted in the down regulation of the SOD1 protein and elevated oxidative stress under conditions where SOD1 production was suppressed. Taken together, these data indicate that SOD1 plays a pivotal role in protecting motor neuron function against TCE toxicity.
Volume 79
Pages 83-90
Published 2016-8-1
DOI 10.1016/j.yrtph.2016.05.007
PII S0273-2300(16)30110-6
PMID 27166294
MeSH Animals Behavior, Animal / drug effects* Brain / drug effects* Brain / enzymology Brain / pathology Brain / physiopathology Cell Line, Tumor Dopaminergic Neurons / drug effects Dopaminergic Neurons / enzymology Dopaminergic Neurons / pathology Genotype Mice, Knockout Motor Activity / drug effects* Neuroblastoma / enzymology Neuroblastoma / pathology Neurotoxicity Syndromes / enzymology Neurotoxicity Syndromes / etiology* Neurotoxicity Syndromes / genetics Neurotoxicity Syndromes / physiopathology Oxidative Stress / drug effects Phenotype Rotarod Performance Test Superoxide Dismutase-1 / deficiency* Superoxide Dismutase-1 / genetics Time Factors Trichloroethylene / toxicity*
IF 2.652
Human and Animal Cells NB2a(RCB2639)