論文 - 詳細
| RRC ID | 61910 |
|---|---|
| 著者 | Hikasa M, Yamamoto E, Kawasaki H, Komai K, Shiozawa K, Hashiramoto A, Miura Y, Shiozawa S. |
| タイトル | p21waf1/cip1 is down-regulated in conjunction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Features characteristic to rheumatoid arthritis (RA) including synovial overgrowth and joint destruction are experimentally produced by augmenting c-fos gene expression. We show that cyclin dependent kinase inhibitor p21waf1/cip1, that inhibits cell proliferation, is down-regulated in conjunction with up-regulation of c-fos in the lymphocytes of patients with RA. As to the mechanism of down-regulation of p21waf1/cip1 gene expression, transfection studies in U937 cells showed that c-fos down-regulated phosphorylation and dimerization of signal transducers and activators of transcription (STAT) 1, thereby inhibiting interferon -induced transactivation of p21waf1/cip1. Phosphorylation of STAT1 was indeed decreased in the lymphocytes of patients with RA. Thus, under overexpression of c-fos gene, c-Fos inactivates STAT1 to down-regulate p21waf1/cip1 gene expression in the lymphocytes of patients with RA, and in this way may enhance proliferation of lymphocytes. |
| 巻・号 | 304(1) |
| ページ | 143-7 |
| 公開日 | 2003-4-25 |
| DOI | 10.1016/s0006-291x(03)00574-6 |
| PII | S0006291X03005746 |
| PMID | 12705898 |
| MeSH | Arthritis, Rheumatoid / genetics Arthritis, Rheumatoid / immunology Arthritis, Rheumatoid / metabolism* Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 Cyclins / genetics* Cyclins / metabolism DNA-Binding Proteins / metabolism Down-Regulation Humans Interferon-gamma / pharmacology Lymphocytes / metabolism* Models, Biological Proto-Oncogene Proteins c-fos / metabolism* Proto-Oncogene Proteins c-fos / physiology STAT1 Transcription Factor Social Control, Formal Trans-Activators / metabolism Transcriptional Activation U937 Cells Up-Regulation |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | U-937 DE-4(RCB0435) |